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SARS-CoV-2 related pneumonia in an adult with cystic fibrosis: natural favourable clinical course or effective therapy?

Giglia, Maddalena; Beci, Giacomo; Rosselli Del Turco, Elena; Guardigni, Viola; Amedeo, Alberto; Cucchetto, Giulia; Verucchi, Gabriella; Cipolli, Marco; Calza, Leonardo; Viale, Pierluigi.

Monaldi Arch Chest Dis ; 90(4)2020 Dec 23.

Article in English | MEDLINE | ID: covidwho-1042105

ABSTRACT

We report the case of a man affected by cystic fibrosis who developed a severe SARS-CoV-2 related pneumonia in March 2020. In addition to lopinavir/ritonavir and hydroxychloroquine, he was treated with two doses of tocilizumab, displaying a significant clinical improvement. This is the first case described in the literature of an adult patient affected by cystic fibrosis who received tocilizumab for COVID-19, with documented total recovery, also assessed by a spirometry.

Subject(s)

Antibodies, Monoclonal, Humanized/administration & dosage , COVID-19 Drug Treatment , COVID-19 , Cystic Fibrosis , Hydroxychloroquine/administration & dosage , Lopinavir/administration & dosage , Pneumonia, Viral , Respiratory Tract Infections/microbiology , Ritonavir/administration & dosage , SARS-CoV-2/isolation & purification , Adult , Antiviral Agents/administration & dosage , COVID-19/complications , COVID-19/diagnosis , COVID-19/physiopathology , Cystic Fibrosis/complications , Cystic Fibrosis/immunology , Cystic Fibrosis/physiopathology , Drug Combinations , Humans , Lung/diagnostic imaging , Lung/physiopathology , Male , Oxygen Inhalation Therapy/methods , Pneumonia, Viral/diagnosis , Pneumonia, Viral/drug therapy , Pneumonia, Viral/etiology , Receptors, Interleukin-6/antagonists & inhibitors , Respiratory Function Tests/methods , Respiratory Tract Infections/drug therapy , Respiratory Tract Infections/etiology , Tomography, X-Ray Computed/methods , Treatment Outcome

ABSTRACT

Subject(s)

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